GLP-X Super Evolution

What is this ingredient? Garcinia cambogia is a small tropical fruit whose rind is rich in (−)‑hydroxycitric acid (HCA). HCA competitively inhibits ATP‑citrate lyase, a key enzyme that converts citrate to acetyl‑CoA for de novo lipogenesis. On this basis, Garcinia has been promoted for weight management and support of body composition. Clinical data are mixed: a 12‑week randomized, double‑blind, placebo‑controlled trial in overweight adults using 1500 mg/day HCA found no significant additional weight or fat loss beyond what was achieved with diet alone [1].

However, more recent systematic reviews and dose‑response meta‑analyses pooling multiple randomized controlled trials report small, statistically significant effects. One meta‑analysis of eight RCTs (530 subjects) found that Garcinia supplementation reduced body weight by about 1.3 kg, BMI by ~1 kg/m², fat mass percentage, and waist circumference by ~4 cm compared with placebo [2]. Another earlier meta‑analysis likewise concluded that HCA can cause short‑term weight loss, though the magnitude is modest and heterogeneity across trials is considerable [3]. At commonly used doses, safety profiles have generally been acceptable, with gastrointestinal symptoms as the most frequent side effect [1,3].

Why include it in this formula? The name “GLP-X Super Evolution - 30” and the complex ingredient list (Garcinia, cactus and pitaya fruits, kidney bean protein, bitter melon peptide, cinnamon, mulberry, AKK/GLP‑X components, etc.) clearly point to a product aimed at metabolic, appetite, and weight‑management support. Within that design, Garcinia cambogia is the primary "lipogenesis and appetite" pillar. By inhibiting ATP‑citrate lyase, HCA may slightly reduce conversion of excess carbohydrate into fat and, in some studies, has been associated with modest reductions in body weight and waist circumference [2,3].

Here it is combined with ingredients that target complementary mechanisms: starch blocking (white kidney bean), GLP‑1/GLP‑X and gut‑microbiome modulation (bitter melon peptide, AKK, fibers), glycemic control (mulberry leaf, cinnamon, bitter melon), and satiety (cactus fruit, protein/peptides). In this context, Garcinia is not expected to be a stand‑alone fat‑loss solution, but a modest contributor to a broader, multi‑pathway metabolic formula that works best alongside calorie‑aware eating and movement.

References

• [1] Heymsfield SB et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9820262/?utm_source=openai))
• [2] Hasani‑Ranjbar S et al. Effect of Garcinia cambogia supplement on obesity indices: a systematic review and dose‑response meta‑analysis of randomized controlled trials ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32951714/?utm_source=openai))
• [3] Onakpoya I et al. The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta‑analysis of randomised clinical trials ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21197150/?utm_source=openai))

What is this ingredient? “Cactus Fruit” in metabolic supplements typically refers to prickly pear (Opuntia) fruit, a cactus berry rich in viscous fibers (pectins and mucilage), vitamin C, betalain pigments, and polyphenols. These components give cactus fruit notable water‑holding capacity and antioxidant activity. The gel‑like fibers can slow gastric emptying and carbohydrate absorption, which may help blunt post‑meal glucose excursions and prolong satiety when taken with food.

Human trials with prickly pear fruit or cladode preparations have reported reductions in post‑prandial blood glucose and modest improvements in lipid parameters in individuals with metabolic syndrome or type 2 diabetes when used alongside diet. The high fiber and water content also supports regularity and may reduce perceived appetite by increasing gastric volume and viscosity.

Why include it in this formula? From the name “GLP-X Super Evolution - 30” and the ingredient list—Garcinia, cactus fruit, pitaya, AKK/GLP‑X components, mulberry leaf, kidney bean protein, cinnamon, bitter melon peptide, and others—it is clear this product targets appetite, glycemic control, and weight‑management pathways, likely with a focus on GLP‑1/GLP‑X and gut–brain signaling. Within this design, cactus fruit is the "fiber–satiety and post‑meal" pillar.

Its viscous fibers and gel‑forming polysaccharides can help slow carbohydrate absorption and enhance feelings of fullness, complementing Garcinia’s effects on lipogenesis, white kidney bean’s starch‑blocking, mulberry and bitter melon’s glycemic support, and any GLP‑focused components that influence incretin signaling. The fruit’s antioxidant pigments add another layer of redox support in the metabolic milieu. In short, cactus fruit helps the formula address the behavioral side of weight management—how quickly you feel full and how sharply blood sugar rises after meals—while other actives work on deeper enzymatic and hormonal pathways.

What is this ingredient? “Tizepe Pitaya” appears to refer to pitaya (dragon fruit), a cactus fruit from genera such as Hylocereus and Stenocereus. Pitaya pulp is rich in betalain pigments (betacyanins and betaxanthins), phenolic acids, flavonoids, vitamin C, and soluble fiber. These compounds contribute to strong antioxidant capacity and vivid red or pink color. Detailed phytochemical profiling of pitaya has identified high total polyphenol content and potent in vitro antioxidant activity across several assays, as well as cellular antioxidant effects in model systems ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40843958/?utm_source=openai)).

Pre‑clinical research suggests that pitaya extracts may improve metabolic parameters. In high‑fat–diet mice, white pitaya juice attenuated insulin resistance, hepatic steatosis, and adipose hypertrophy, while modulating hepatic genes involved in lipid and cholesterol metabolism and FGF21 signaling ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26914024/?utm_source=openai)). Other work shows that pitaya fruit or peel extracts can reduce oxidative stress and inflammation, inhibit digestive enzymes such as α‑glucosidase and pancreatic lipase, and beneficially affect intestinal microenvironment models, supporting roles in glycemic control and fat handling ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35945808/?utm_source=openai)).

Why include it in this formula? From the name “GLP‑X Super Evolution - 30” and its ingredient list—Garcinia, cactus fruit, pitaya, AKK/GLP‑X components, mulberry leaf, kidney bean protein, cinnamon, bitter melon peptide, goldenseal, and perilla peptides—the product is clearly designed for metabolic and weight‑management support, likely emphasizing gut‑hormone and GLP‑1/GLP‑X pathways. Within this architecture, pitaya serves as a “metabolic–antioxidant fruit” pillar. Its betalains and polyphenols add substantial antioxidant capacity and may help counter diet‑induced oxidative stress and low‑grade inflammation that accompany obesity and insulin resistance ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40843958/?utm_source=openai)).

The preclinical evidence that pitaya juice improves insulin resistance and fatty‑liver markers in diet‑induced obese mice ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26914024/?utm_source=openai)) aligns well with other ingredients in the blend that target glucose absorption (mulberry, kidney bean), lipogenesis (Garcinia), and incretin or gut‑microbiome dynamics (bitter melon peptide, AKK/GLP‑X). In practical terms, “Tizepe Pitaya” contributes a nutrient‑dense, fiber‑ and polyphenol‑rich fruit matrix that supports glycemic control, hepatic lipid handling, and redox balance, helping round out the product’s multi‑pathway approach to modern metabolic health.

References

• [1] White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet‑Induced Obese Mice ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26914024/?utm_source=openai))
• [2] Pre‑clinical evidence for the therapeutic effect of Pitaya (Hylocereus lemairei) on diabetic intestinal microenvironment ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35945808/?utm_source=openai))
• [3] Phytochemical and Antioxidant Profile of Pitaya (Hylocereus hybridum) Fruits: Elucidation Through Chemical Fractionation ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40843958/?utm_source=openai))