UROLITHIN A

What is this ingredient? Vitamin C, usually provided as ascorbic acid, is an essential water‑soluble vitamin that humans must obtain from diet or supplements. It serves as a key antioxidant, directly scavenging reactive oxygen species and helping regenerate other antioxidants such as vitamin E. In connective tissues, vitamin C is an obligate cofactor for prolyl and lysyl hydroxylases, enzymes that hydroxylate proline and lysine during collagen synthesis, allowing formation of stable, properly cross‑linked collagen fibers [0,6]. Deficiency impairs collagen maturation and leads to fragile blood vessels, poor wound healing, and classic scurvy symptoms.

At the cellular level, vitamin C also modulates gene expression and myofibroblast phenotype through TGF‑β–related pathways, influencing how new matrix is laid down and remodeled [6]. In systemic trials, correcting low vitamin C status improves plasma antioxidant capacity and may support perceived health and resilience, especially in older adults whose baseline intakes are often marginal [5].

Why include it in this formula? The UROLITHIN A - 60 product combines vitamin C, urolithin A, and resveratrol—ingredients strongly associated with mitochondrial function, cellular maintenance, and healthy aging. Within this architecture, vitamin C plays the "antioxidant and matrix‑support" pillar. Urolithin A primarily targets mitophagy and mitochondrial health, and resveratrol targets mitochondrial signaling and vascular function; both can transiently increase oxidative and metabolic flux. Vitamin C helps buffer this redox activity, protecting lipids, proteins, and DNA from excess oxidative stress while these pathways are being nudged [0,5,8].

By supporting collagen maturation, vitamin C also underpins structural tissues—blood vessels, tendons, and muscle extracellular matrix—that must adapt as mitochondrial efficiency improves. In combination with urolithin A’s effects on muscle endurance and mitochondrial biomarkers and resveratrol’s exploration as an exercise‑adjunct in older adults [0,4,9], vitamin C helps create a more stable structural and redox environment. That synergy aligns with the product’s goal: not just to stimulate cellular renewal pathways, but to do so while maintaining robust antioxidant protection and connective‑tissue integrity.

References

• [0] Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
• [4] Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial
• [5] The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial
• [6] Ascorbic acid promotes a TGFβ1-induced myofibroblast phenotype switch
• [8] High-dose antioxidant vitamin C supplementation does not prevent acute exercise-induced increases in markers of skeletal muscle mitochondrial biogenesis in rats

What is this ingredient? StanYouth® Urolithin A refers to a branded form of urolithin A, a gut‑microbiome–derived metabolite normally produced from ellagitannins in foods like pomegranate, some berries, and nuts. Urolithin A has attracted attention as a “mitophagy activator”—a compound that can stimulate the selective recycling of damaged mitochondria. In a first‑in‑human trial, daily oral urolithin A in older sedentary adults was safe and induced a molecular signature of improved mitochondrial and cellular health, including modulation of plasma acylcarnitines and up‑regulation of mitochondrial gene expression in skeletal muscle [0].

Subsequent randomized, placebo‑controlled trials in middle‑aged and older adults showed that 4 months of urolithin A supplementation significantly improved muscle endurance and leg strength and reduced circulating acylcarnitines and C‑reactive protein, indicating more efficient mitochondrial fat utilization and lower inflammatory tone [0,1]. Together with robust preclinical data demonstrating enhanced mitophagy, improved exercise capacity, and extended healthspan in animal models [3,4], these studies support urolithin A as a promising cellular‑health and muscle‑function ingredient.

Why include it in this formula? The UROLITHIN A - 60 product pairs vitamin C, StanYouth® Urolithin A, and resveratrol, clearly targeting mitochondrial function, cellular maintenance, and healthy aging. Within this architecture, StanYouth® Urolithin A is the central "mitophagy and muscle‑endurance" pillar. By enhancing mitophagy and shifting mitochondrial biomarkers toward a more youthful profile in human trials [0,1], it addresses a root cause of age‑associated fatigue—accumulation of dysfunctional mitochondria—rather than just masking low energy.

Resveratrol provides complementary support for mitochondrial signaling and vascular function, while vitamin C buffers redox stress and supports collagen‑rich tissues that must adapt as mitochondrial efficiency improves. This three‑part design means StanYouth® Urolithin A is not working in isolation: its mitophagy‑activating and endurance‑supporting effects are reinforced by antioxidants and polyphenols that protect structures around the muscle and vascular systems, aligning the product with a broader goal of sustainable, cellular‑level rejuvenation.

References

• [0] The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
• [1] Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle‑aged adults
• [3] Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

What is this ingredient? Resveratrol is a polyphenol found naturally in grapes, red wine, and some berries and nuts. It is widely studied as a calorie‑restriction–mimetic compound because it can activate cellular energy‑sensing pathways, including SIRT1 and AMPK, in experimental models. Through these pathways, resveratrol influences mitochondrial biogenesis, oxidative stress responses, and inflammatory signaling. In humans, randomized controlled trials show that resveratrol supplementation can improve endothelial function, with meta‑analyses reporting significant increases in flow‑mediated dilation and reductions in adhesion molecules such as ICAM‑1 in people with metabolic syndrome and related disorders [0,1].

Resveratrol has also demonstrated anti‑inflammatory effects in individuals at risk of coronary artery disease, including dose‑dependent reductions in TNF‑α and increased eNOS expression in primary prevention settings [2]. Pilot trials combining resveratrol with exercise in older adults suggest good tolerability and feasibility and are exploring whether it can augment exercise‑induced gains in mitochondrial function and physical performance [3,4].

Why include it in this formula? The UROLITHIN A - 60 product pairs vitamin C, urolithin A, and resveratrol—ingredients clearly aimed at supporting mitochondrial health, vascular function, and healthy aging. Within this architecture, resveratrol is the "SIRT1/AMPK and vascular" pillar. While urolithin A primarily stimulates mitophagy and mitochondrial renewal, resveratrol helps tune upstream energy‑sensing networks and improves endothelial function, as shown by significant improvements in flow‑mediated dilation in randomized trials and meta‑analyses [0,1].

Resveratrol’s ability to reduce inflammatory mediators like TNF‑α and enhance eNOS‑related nitric‑oxide signaling in at‑risk individuals [1,2] complements vitamin C’s antioxidant and collagen‑support roles and urolithin A’s mitochondrial actions. Together, these ingredients create a coordinated "cellular rejuvenation" environment: urolithin A renews mitochondria, resveratrol supports energy‑sensing and vascular health, and vitamin C stabilizes redox balance and connective tissues. This synergy aligns with the product’s goal of supporting endurance, vascular resilience, and long‑term cellular vitality rather than providing only short‑term stimulation.

References

• [0] Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials
• [1] The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
• [2] Resveratrol as an Anti-inflammatory Agent in Coronary Artery Disease: A Systematic Review, Meta-Analysis and Meta-Regression
• [3] Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial
• [4] Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial