Nicotinamide Riboside (NR) + Resveratrol - Supports NAD+ Pathways - 120 Capsules

Vitamin D3

Vitamin D3 (cholecalciferol) is a fat-soluble vitamin and hormone precursor made in the skin from sunlight and obtained from diet or supplements. In the body, it is converted to 25-hydroxyvitamin D (25(OH)D), then to the active hormone that binds the vitamin D receptor (VDR) to regulate gene expression in many tissues—best known for supporting calcium and phosphorus balance and overall vitamin D status.[1] Beyond skeletal health, VDR signaling has been linked to skeletal muscle energy metabolism; controlled fluctuations in vitamin D status have been shown to modulate muscle mitochondrial oxidative capacity and ATP-linked respiration in human/animal models, connecting adequate vitamin D status with more efficient muscle bioenergetics.[2] Vitamin D signaling is also widely recognized for its role in immune regulation through VDR-expressing immune cells and downstream immunomodulatory pathways.[3]

What it does in this formula

In Fmlave NAD+, Vitamin D3 is included as a foundational nutrient to help maintain healthy vitamin D status—supporting muscle function and immune readiness that align with a daily vitality and healthy-aging formula. While Fmlave NAD+ focuses on cellular energy support through its NAD+ precursor approach, Vitamin D3 helps strengthen the “baseline environment” (muscle bioenergetics and immune regulation) that many people want to keep solid as they pursue better everyday resilience.

References

[1] Demay MB, et al. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2024.

[2] Salles J, et al. Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle. Communications Biology. 2022.

[3] Artusa P, et al. Vitamin D and its analogs in immune system regulation. Pharmacol Rev. 2025.

Nicotinamide Riboside (NR) (as hydrogen malate)

Nicotinamide riboside (NR)—sometimes called niacin riboside—is a naturally occurring form of vitamin B3 made of nicotinamide linked to ribose. Unlike niacin (nicotinic acid) or niacinamide (nicotinamide), NR enters the vitamin B3 salvage network as a nucleoside and is phosphorylated by nicotinamide riboside kinases (NRK1/NRK2) into nicotinamide mononucleotide (NMN), which is then converted into a central cellular dinucleotide coenzyme used for redox metabolism and as a substrate for enzymes like sirtuins and PARPs.[1]

What it does in this formula

In Fmlave NAD+, NR (as hydrogen malate) is the primary NAD+ precursor—supplying 500 mg per serving to help replenish NAD+ levels that support mitochondrial ATP production and fuel NAD-dependent enzymes involved in cellular repair signaling, stress responses, and healthy aging. In a randomized, placebo-controlled human trial, oral NR significantly increased measured NAD+ metabolites (and related metabolites) versus placebo, confirming real-world bioavailability and pathway engagement.[2] The hydrogen malate form is a crystalline salt developed for manufacturing and stability while delivering the same active NR once dissolved.[3]

References

[1] Damgaard MV, Treebak JT. What is really known about the effects of nicotinamide riboside supplementation in humans? Science Advances. 2023.

[2] Orr ME, et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults. Geroscience. 2024.

[3] Schabert G, et al. New crystalline salts of nicotinamide riboside as food additives. Molecules. 2021.

Quercetin Phytosome (from Sophora japonica) (Flower) (20:1 extract)

Quercetin is a naturally occurring flavonol (a type of plant polyphenol) found across many fruits, vegetables, and botanicals. It’s especially discussed for its role in helping the body manage oxidative and inflammatory stress signals, and it is rapidly metabolized after absorption into circulating conjugated forms (such as glucuronides and sulfates), which is one reason conventional quercetin can show variable uptake between people. “Phytosome” refers to a phospholipid (lecithin) complex delivery approach designed to improve oral absorption by pairing quercetin with a lipid-compatible carrier. In a 2025 systematic review and meta-analysis of human intervention studies on quercetin bioavailability, lecithin phytosome formulations showed large increases in measured bioavailability versus unformulated quercetin, including ~20-fold improvements reported in the included studies.[1] “20:1 extract” indicates a concentration ratio of the botanical starting material (here, Sophora japonica flower) into an extract; it describes the extraction concentration process, but does not automatically mean the finished ingredient contains 20× the quercetin content unless a separate standardization is specified.

What it does in this formula

In Fmlave NAD+, Quercetin Phytosome is included as a highly bioavailable polyphenol to complement the formula’s broader “cellular resilience” design—helping reinforce antioxidant defenses and stress-response balance alongside other botanicals in the blend. Human evidence also supports quercetin’s relevance to everyday cardiometabolic wellness; a 2024 systematic review and dose–response meta-analysis of randomized controlled trials reported modest improvements across multiple cardiometabolic wellness markers in adults receiving quercetin supplementation.[2] And for active users, a systematic review and meta-analysis of randomized trials found quercetin supplementation supported recovery-related outcomes after intense exercise, including reduced soreness and lower post-exercise oxidative-stress markers—useful context for a longevity-oriented daily stack that aims to keep performance and recovery “online.”[3]

References

[1] Liu L, Barber E, Kellow NJ, Williamson G. Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies. Food Chemistry. 2025.

[2] Noshadi N, et al. Quercetin supplementation in adults: a systematic review and dose–response meta-analysis of randomized controlled trials. Journal of Functional Foods. 2024.

[3] Rojano-Ortega D, et al. Quercetin supplementation promotes recovery after exercise-induced muscle damage: a systematic review and meta-analysis of randomized controlled trials. Biology of Sport. 2023.

Resveratrol

Resveratrol (3,5,4′-trihydroxystilbene) is a naturally occurring stilbene polyphenol (a plant phytoalexin), most often discussed as trans-resveratrol. Plants produce it as part of their defense response, and supplemental resveratrol is commonly sourced from Japanese knotweed root (Polygonum cuspidatum), a naturally stilbene-rich botanical. This ingredient is a 20:1 root extract, meaning 20 parts of raw root are concentrated into 1 part of extract to deliver a higher density of the root’s polyphenols per serving. Mechanistically, resveratrol is known to influence antioxidant and inflammatory signaling (including Nrf2- and NF-κB–linked pathways), and to interact with cellular energy and stress-response regulators (such as AMPK and SIRT1) that shape mitochondrial function and autophagy. In humans, a key practical point is pharmacokinetics: resveratrol is absorbed but rapidly metabolized (e.g., glucuronidation and sulfation), so blood levels of unmetabolized resveratrol are typically low while conjugated metabolites predominate—one reason extracts and delivery strategies are used in supplements.[1]

What it does in this formula

In Fmlave NAD+, resveratrol adds a polyphenol layer that supports a healthy inflammatory response; an umbrella meta-analysis of randomized evidence reported reductions in key inflammatory biomarkers including inflammation-related markers with resveratrol supplementation.[2]
Resveratrol also supports vascular endothelial function—an RCT meta-analysis reported improvements in measures of vascular function, a functional marker of endothelial health.[3]
Paired with the formula’s NAD+ precursor approach, Fmlave NAD+ is designed to support daily energy availability while also strengthening the metabolic and oxidative-stress environment that shapes long-term resilience.

References

[1] Ren Z, et al. Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects. MedComm. 2025.

[2] Molani-Gol R, et al. Effects of resveratrol on the anthropometric indices and inflammatory markers: an umbrella meta-analysis. Eur J Nutr. 2024.

[3] Mohammadipoor N, et al. Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022.

Shilajit

Shilajit (Asphaltum Punjabianum)—also known as mumijo/mumie—is a dark, humic, mineral-rich material that forms over time as plant and microbial matter naturally transforms and concentrates in high-altitude rock environments, then is collected and purified for dietary use. Chemically, it’s a complex of humic substances (often fulvic- and humic-acid fractions), dibenzo-α-pyrones and related organic compounds, plus naturally occurring trace minerals that together define its “phyto-mineral” profile.[1] Because composition can vary by region and harvest, modern quality-controlled shilajit is typically characterized with analytical fingerprinting (e.g., chromatographic and spectroscopic methods) to confirm identity and consistency from batch to batch.[2] A 30:1 extract indicates a concentration ratio used to produce the extract from the starting material, helping deliver a more concentrated shilajit profile per serving.

What it does in this formula

In Fmlave NAD+, shilajit is included as a “resilience layer” alongside the formula’s polyphenols—supporting stamina and recovery-related signals when daily output is being taxed. In an 8-week double-blind, placebo-controlled human study, purified shilajit at 500 mg/day helped retain maximal muscular strength after a fatiguing protocol and lowered serum hydroxyproline, a biomarker commonly used in research as a readout tied to connective-tissue turnover and stress.[3] That human evidence is why shilajit fits this kind of longevity-oriented stack: it’s selected to complement performance and recovery context, not to act as a stimulant.

References

[1] Basavaraja D, et al. Chemical Analysis of Native Himalayan Shilajit: An Evaluation of an Ayurvedic Formulation. ACS Omega. 2025.

[2] Ding R, et al. Efficient generation of HPLC and FTIR data for quality assessment using time series generation model: a case study on Tibetan medicine Shilajit (Zhaxun). Front Pharmacol. 2024.

[3] Keller JL, et al. The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels. J Int Soc Sports Nutr. 2019.

Fisetin

Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a naturally occurring flavonol—a subclass of plant polyphenols—best known for its antioxidant activity and its role in modern “healthy aging” research. It appears in small amounts across various foods (with strawberries often cited as a notable dietary source), and it’s also produced as a concentrated botanical extract for supplement use. Research interest has grown because fisetin interacts with multiple cell-signaling systems tied to oxidative stress control, inflammatory tone, and cellular senescence biology—one reason it is frequently discussed as a potential “senotherapeutic” polyphenol in aging science.[1] In this formula, the fisetin is supplied as a 20:1 leaf extract from smoke tree (Cotinus coggygria), meaning 20 parts of starting leaf material are concentrated into 1 part extract to deliver a more potent polyphenol fraction per serving. Because fisetin is known to have low water solubility and can be rapidly metabolized after oral intake, real-world delivery is a key consideration in supplementation.[2]

What it does in this formula

In Fmlave NAD+, fisetin adds a “polyphenol support layer” designed to complement the formula’s broader longevity profile: it helps reinforce antioxidant defenses, supports a healthy inflammatory response, and targets senescence-related signaling that becomes more relevant with age and high-stress lifestyles. Conceptually, this supports the environment where your cells operate—helping the body stay more resilient under oxidative and metabolic pressure—while fitting naturally alongside other plant-actives in the blend that are selected for cellular protection and recovery-focused support.[3]

References

[1] Tavenier J, et al. Fisetin as a senotherapeutic agent: Evidence and perspectives. Mechanisms of Ageing and Development. 2024.

[2] Krishnakumar IM, et al. Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study. J Nutr Sci. 2022.

[3] Della Vedova L, et al. The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action. Pharmaceuticals (Basel). 2025.

Grape Seed Extract

Grape Seed Extract (from Vitis vinifera seeds) is best known as a dense source of flavan-3-ol polyphenols—especially proanthocyanidins (often called OPCs or procyanidins), which are naturally occurring chains of catechin/epicatechin units. In supplements, grape seed is typically used as an enriched polyphenol fraction because seeds are one of the grape’s most proanthocyanidin-rich parts. A 30:1 extract ratio indicates that 30 parts of starting seed material are concentrated into 1 part extract to deliver a higher-intensity polyphenol profile per serving (the ratio reflects concentration of the starting material, not a guaranteed percent-standardization by itself). Due to their structure, many proanthocyanidins have limited absorption intact; a major part of their biological activity is thought to occur in the gastrointestinal tract and through downstream metabolites formed during digestion and by the gut microbiota.[1] In pharmacokinetic research, measurable circulating phenolic metabolites appear after intake, and factors like dosing timing and diet can shift the plasma metabolite pattern—highlighting why “delivery” and metabolism matter for real-world use.[3]

What it does in this formula

In Fmlave NAD+, grape seed extract is included as a proanthocyanidin-rich polyphenol layer that supports antioxidant defenses and blood-vessel resilience—useful for a daily “long-game” formula designed to feel steady over months, not spiky over hours. Human data also suggest grape seed extract can support vascular-function outcomes in controlled trials, consistent with support for healthy circulation and cardiovascular comfort.[2] And because polyphenol bioavailability matters, the timing of grape seed extract administration can influence plasma levels of key metabolites, which is one reason this formula is designed for consistent daily use.[3]

References

[1] Zhu F, Oteiza PI. Proanthocyanidins at the gastrointestinal tract: mechanisms involved in their capacity to support metabolic resilience. Crit Rev Food Sci Nutr. 2024.

[2] Foshati S, et al. The effect of grape (Vitis vinifera) seed extract supplementation on measures of vascular function and circulation-related outcomes: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis. Pharmacol Res. 2022.

[3] Escobar-Martínez L, et al. Administration time significantly affects plasma bioavailability of grape seed proanthocyanidins extract in Fischer 344 rats. Mol Nutr Food Res. 2022.

Rose Hips

Rose hips (Rosa canina L.), often called rosehip or dog rose, are the bright red-orange pseudo-fruits that form after the rose flower drops its petals. For supplement use, the dried fruit is milled or extracted to concentrate a naturally broad nutrient-and-polyphenol profile—especially vitamin C, carotenoids (such as beta-carotene and lycopene), and diverse phenolics including flavonoids and phenolic acids.[1] Because these compounds span both water- and fat-associated fractions, rose hip is commonly discussed as a “whole-fruit” antioxidant ingredient that helps support the body’s normal oxidative balance. Chemical profiling of commercially available R. canina dried fruit has confirmed measurable carotenoids, high total polyphenols, and strong in vitro antioxidant activity across multiple standard assays, reflecting this multi-compound makeup.[2] A 20:1 fruit extract means 20 parts of starting rose hip material are concentrated into 1 part extract, helping deliver more of the fruit’s bioactive fraction in a compact serving.

What it does in this formula

In Fmlave NAD+, rose hips add a gentle, food-based vitamin C + carotenoid layer that supports antioxidant recycling and collagen formation—helping reinforce connective-tissue and skin structural support—while broadening the formula’s plant-polyphenol spectrum alongside quercetin, resveratrol, grape seed, turmeric, green tea, and acai.[3] The goal is a more complete “daily resilience” profile: cellular protection, recovery-friendly support, and a steadier, more balanced feel under everyday stress.

References

[1] Kumar A, et al. Rosehip (Rosa canina L.): Nutritional profile, bioactive compounds, extraction, and applications. Food and Humanity. 2025.

[2] Miljković VM, et al. Chemical Profile and Antioxidant and Antimicrobial Activity of Rosa canina L. Dried Fruit Commercially Available in Serbia. International Journal of Molecular Sciences. 2024.

[3] Oargă DP, et al. Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review. Frontiers in Pharmacology. 2024.

Turmeric

Turmeric (Curcuma longa) is the golden-orange rhizome commonly used as a culinary spice and botanical ingredient. Its most studied actives are curcuminoids—especially curcumin—along with related compounds that contribute to turmeric’s antioxidant and inflammation-balancing profile. Mechanistically, curcumin is widely described as modulating redox and inflammatory signaling networks (including NF-κB- and Nrf2-linked pathways) that influence oxidative-stress handling and immune tone.[1] A key practical point is absorption: curcuminoids naturally have low oral bioavailability, so formulations often pair turmeric with bioavailability-support strategies such as piperine (from black pepper).[2]

What it does in this formula

In Fmlave NAD+, turmeric is included as a gentle “inflammation + antioxidant” layer to complement the formula’s broader polyphenol stack (quercetin, resveratrol, grape seed, green tea, acai). It’s designed to help support day-to-day recovery signals and oxidative balance—especially useful when stress, training, or irregular sleep ramps up systemic wear-and-tear. In pooled human-trial evidence, curcumin supplementation has been associated with improvements in inflammatory and oxidative-stress across common inflammatory and oxidative-stress biomarkers across randomized controlled trials, consistent with its role as a daily resilience ingredient.[3]

References

[1] Cui J, et al. Research progress on the mechanism of curcumin anti-inflammatory effect. Front Pharmacol. 2025.

[2] Karimi M, et al. Effects of Curcuminoids Plus Piperine Co-Supplementation: A Systematic Review and Meta-Analysis. Phytother Res. 2025.

[3] Kavyani Z, et al. The effects of curcumin supplementation on biomarkers of inflammation, oxidative stress, and endothelial function: a systematic review and meta-analysis of RCTs. J Am Coll Nutr. 2024.

Acai

Acai (Euterpe oleracea) is a dark purple Amazonian palm fruit best known for its anthocyanins—pigments in the flavonoid family that contribute to acai’s deep color and antioxidant profile. Beyond anthocyanins, acai contains other polyphenols (including flavonoids and phenolic acids) plus naturally occurring lipids and phytosterols that together create a distinctive “whole-fruit” phytochemical spectrum. Modern food-chemistry reviews describe acai as a polyphenol-dense berry with measurable antioxidant capacity across standard assays, and human nutrition research often evaluates it for oxidative-balance, cardiometabolic, and recovery-oriented outcomes.[1] A 10:1 fruit extract indicates that 10 parts of starting acai fruit material are concentrated into 1 part extract to deliver more of the fruit’s bioactive fraction per serving.

What it does in this formula

In Fmlave NAD+, acai adds a food-based anthocyanin layer that broadens the formula’s polyphenol spectrum alongside quercetin, resveratrol, grape seed, turmeric, and green tea. It’s included to support antioxidant balance and post-stress recovery signals—useful for a daily longevity stack designed to keep performance, skin tone, and overall resilience “online” under real-life load. In a randomized, placebo-controlled human trial, acai intake improved antioxidant status and reduced markers tied to oxidative stress, consistent with its role as a dietary antioxidant support ingredient.[2] Acai polyphenols have also been studied for supporting endothelial and lipid-related cardiometabolic markers, reinforcing why it pairs well with vascular-supportive botanicals in this formula.[3]

References

[1] Barbosa PO, et al. Açaí (Euterpe oleracea Mart.) and its health benefits: a comprehensive review on bioactive composition and mechanisms. Food Chemistry. 2024.

[2] Udani JK, et al. Effects of açaí (Euterpe oleracea) pulp on antioxidant status and oxidative stress markers: a randomized, placebo-controlled trial. Nutrients. 2022.

[3] Souza MO, et al. Açaí (Euterpe oleracea) polyphenols and cardiometabolic health: evidence from human trials and mechanistic insights. Front Nutr. 2023.

Green Tea Extract

Green tea (Camellia sinensis) is a non-fermented tea leaf ingredient valued for its concentrated polyphenols, especially catechins such as epigallocatechin gallate (EGCG), epicatechin (EC), epigallocatechin (EGC), and epicatechin gallate (ECG). These catechins are widely studied because they participate in antioxidant defense and cell-signaling networks involved in oxidative balance and metabolic regulation, including pathways commonly discussed around Nrf2- and NF-κB-linked stress responses and AMPK-related energy signaling.[1] A 10:1 leaf extract indicates that 10 parts of starting green tea leaf material are concentrated into 1 part extract to deliver more of the leaf’s bioactive fraction per serving.

What it does in this formula

In Fmlave NAD+, green tea extract is included to support metabolic steadiness and everyday resilience. A large systematic review and meta-analysis of randomized trials reported that green tea supplementation was associated with small, consistent shifts across multiple wellness markers in adults taking green tea supplements.[2] Separately, a grade-assessed meta-analysis of randomized trials found green tea supplementation can improve oxidative-status markers (for example, total antioxidant capacity and oxidation-related measures), aligning with the formula’s “daily protection + recovery-friendly” intent.[3]

References

[1] Alam M, et al. Epigallocatechin-3-gallate (EGCG): molecular mechanisms and clinical research overview. Molecular Biomedicine. 2024.

[2] Zamani M, et al. Green tea supplementation: a systematic review and meta-analysis. Frontiers in Nutrition. 2023.

[3] Dehzad MJ, et al. Effects of green tea supplementation on antioxidant status and inflammatory markers in adults: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials. Journal of Nutritional Science. 2025.

Black Pepper Extract

Black pepper (Piper nigrum) extract is a concentrated botanical ingredient best known for piperine, the naturally occurring alkaloid that gives black pepper much of its characteristic pungency. In supplement science, piperine is widely discussed as a “bioavailability enhancer” because it can influence intestinal uptake and the metabolic processing of certain plant compounds—helping more of a co-ingested ingredient’s active fraction remain available for absorption and circulation.[1] This is why black pepper extract is often paired with polyphenols and other botanicals whose absorption is naturally limited.

What it does in this formula

In Fmlave NAD+, Black Pepper Extract is included as a small but strategic absorption-support component that complements the formula’s polyphenol stack—especially turmeric’s curcuminoids, alongside other plant actives. In a classic human pharmacokinetic study, adding piperine significantly increased measured curcumin bioavailability versus curcumin alone, supporting its practical role as a “delivery assist” in multi-botanical formulas.[2] Consistent with that role, modern systematic reviews of curcuminoid + piperine co-supplementation highlight piperine’s absorption-support purpose and evaluate the combined approach across human trials.[3]

References

[1] Karimi M, et al. Effects of Curcuminoids Plus Piperine Co-Supplementation: A Systematic Review and Meta-Analysis. Phytotherapy Research. 2025.

[2] Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 1998.

[3] Epelde F, et al. A systematic review and meta-analysis of randomized controlled trials of turmeric (curcumin) alone or combined with piperine. 2025.