Menopause Support

Vitamin D3 (Cholecalciferol)

Vitamin D3, also called cholecalciferol, is a fat-soluble vitamin that can be synthesized in skin under UVB light and is also obtained from foods and supplements. Once in the body, D3 is converted to 25-hydroxyvitamin D in the liver and then to the hormonally active form, 1,25-dihydroxyvitamin D, primarily in the kidneys, creating the basis for how vitamin D status is measured and discussed clinically.[1] Its best-known biological role is supporting calcium and phosphorus absorption and regulation, which helps maintain normal bone mineralization and skeletal function. Beyond bone, vitamin D receptors are widely expressed, and vitamin D has been studied in many physiological systems; however, the strongest, most established human evidence remains centered on bone and mineral metabolism outcomes.[2]

What it does in this formula

In Fmlave Menopause Support, Vitamin D3 is included as a foundational nutrient to support calcium absorption and maintain healthy bones and muscle function—areas that matter for long-term wellness during midlife. It pairs naturally with magnesium citrate (a mineral involved in neuromuscular signaling) and B vitamins (cofactors for everyday energy metabolism) to create a steady daily base, while the botanical blend supports overall comfort and well-being through the transition. The intent is routine-based, structure/function support rather than symptom-specific or drug-like positioning.

References

[1] Office of Dietary Supplements, National Institutes of Health. Vitamin D: Fact Sheet for Health Professionals. NIH. 2026.

[2] Bouillon R, Marcocci C, Carmeliet G, et al. Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev. 2019.

[3] Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2022.

Riboflavin (Vitamin B2)

Riboflavin, also known as vitamin B2, is a water-soluble vitamin that serves as the dietary precursor to two essential flavin coenzymes: flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).[1] These flavins bind to “flavoproteins” that support core redox chemistry throughout human metabolism, including pathways involved in normal energy production, fatty-acid and amino-acid processing, and antioxidant enzyme function.[1] After absorption, riboflavin is taken up by tissues and converted to FMN and FAD, and nutritional status is often discussed using functional markers such as erythrocyte glutathione reductase activation, which reflects flavin-dependent enzyme activity in the body. Because riboflavin participates broadly as a cofactor, it is generally framed as a foundational nutrient that supports normal metabolic function rather than an ingredient tied to a single narrow pathway.

What it does in this formula

In Fmlave Menopause Support, riboflavin is included as part of the daily B-vitamin foundation to support normal energy metabolism and antioxidant systems—two practical pillars for a steady midlife routine. It complements vitamin B6 (another key cofactor for neurotransmitter-related and amino-acid metabolism) and magnesium citrate (important for neuromuscular signaling), helping the formula feel like consistent, day-to-day support. The goal is reliable structure/function support as part of everyday wellness habits, alongside the botanical complex chosen for women’s daily comfort through the transition.

References

[1] Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003.

[2] EFSA NDA Panel. Dietary reference values for riboflavin. EFSA Journal. 2017.

[3] Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academies Press. 1998.

Vitamin B6

Vitamin B6 is the umbrella name for several related vitamers—pyridoxine, pyridoxal, and pyridoxamine—and their phosphorylated forms, with pyridoxal-5′-phosphate (PLP) serving as the primary active coenzyme form in human biology.[1] PLP-dependent enzymes support a wide set of everyday reactions, including amino-acid metabolism and the normal synthesis of signaling molecules used by the nervous system, as well as steps involved in glycogen utilization and one-carbon metabolism. After intake, B6 vitamers are absorbed and converted through a salvage pathway into PLP, which then binds to enzyme active sites to support normal metabolic flow across tissues.[1]

What it does in this formula

In Fmlave Menopause Support, Vitamin B6 is included as a foundational cofactor to support normal energy metabolism and neurotransmitter-related metabolism—helping the daily routine feel more steady and resilient during midlife. It complements riboflavin (B2), which supports flavin-dependent energy and antioxidant pathways, and pairs naturally with magnesium citrate for neuromuscular and relaxation support. As with any vitamin, total intake matters: long-term high supplemental B6 intake from stacking multiple products has been associated with safety concerns, so staying within the labeled serving and considering all sources is a practical approach.[2]

References

[1] Bjørke-Monsen AL, Ueland PM. Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023. Food Nutr Res. 2023.

[2] Turck D, Bohn T, Castenmiller J, et al. Scientific opinion on the tolerable upper intake level for vitamin B6. EFSA Journal. 2023.

[3] O’Leary F, Samman S. Vitamin B6. Nutrients. 2010.

Magnesium (as Magnesium Citrate)

Magnesium is an essential mineral and electrolyte that the body uses as a cofactor in hundreds of enzymatic reactions, including ATP-dependent energy chemistry, protein synthesis, and normal nerve-and-muscle signaling.[1] In supplements it is provided as a magnesium salt, and the “form” matters because it can influence solubility and gastrointestinal tolerance; magnesium citrate is an organic magnesium salt commonly used for its relatively good solubility. After absorption, magnesium circulates largely as Mg2+ and is tightly regulated by intestinal uptake and kidney reabsorption to keep levels in a narrow physiological range. Intestinal transport involves both passive diffusion and active routes, with channels such as TRPM6 and TRPM7 playing key roles in magnesium handling, while the kidneys fine-tune balance by reclaiming filtered magnesium back into the bloodstream.[2]

What it does in this formula

In Fmlave Menopause Support, magnesium citrate is included as a core relaxation-and-steadiness mineral to support healthy nerve-and-muscle function, balanced neuromuscular signaling, and overall daily comfort during midlife. It pairs naturally with Vitamin D3 (which supports calcium absorption and bone health) and B vitamins (riboflavin and B6 as metabolic cofactors), helping the formula function as a dependable daily base alongside the women’s botanical complex. Because supplemental magnesium can cause digestive upset in some people—especially at higher intakes—following the labeled serving and considering total magnesium from all sources is a practical way to keep the routine comfortable and sustainable.[3]

References

[1] Office of Dietary Supplements, National Institutes of Health. Magnesium: Fact Sheet for Health Professionals. NIH. 2026.

[2] Adomako EA, et al. Magnesium Disorders: Core Curriculum 2024. Am J Kidney Dis. 2024.

[3] Henriksen C, et al. Magnesium: a scoping review for Nordic Nutrition Recommendations 2023. Food Nutr Res. 2023.

Dong Quai (Angelica sinensis) Root

Dong quai (Angelica sinensis), also called “dang gui,” is the dried root of an aromatic plant in the Apiaceae family that has a long history of use in East Asian herbal traditions. In modern supplements, the root is commonly used as a powder or concentrated extract, and its chemistry is often discussed in terms of several major compound families: phthalides (notably Z-ligustilide), phenolic acids (such as ferulic acid), polysaccharides, and naturally occurring coumarins.[1] These constituents have been studied for how they may support normal physiological signaling related to vascular tone, oxidative balance, and inflammatory pathways, with polysaccharides in particular frequently evaluated for immune and redox-related mechanisms.[2] Because dong quai contains compounds that can influence platelet function and coagulation pathways, it is commonly discussed in the context of potential interactions with anticoagulant or antiplatelet medications; conservative labeling language typically recommends avoiding use during pregnancy and consulting a clinician when using blood thinners or when managing hormone-sensitive conditions.[3]

What it does in this formula

In Fmlave Menopause Support, dong quai root is included as part of the women’s botanical complex to support daily comfort and overall well-being during the menopausal transition. It’s positioned as a steady, routine-friendly botanical to complement the formula’s foundational nutrients (Vitamin D3, riboflavin, vitamin B6, and magnesium citrate) and other botanicals (such as lemon balm and chasteberry) that support calm mood, sleep-quality habits, and temperature comfort. The intent is consistent, structure/function support that fits an everyday wellness routine—without drug-like or symptom-specific positioning.

References

[1] Ge X, et al. Essential oil of Angelica sinensis: A review of its extraction processes, phytochemistry, pharmacological effects, potential drug delivery systems and applications. Arabian Journal of Chemistry. 2025.

[2] Ren C, et al. Pharmacological action of Angelica sinensis polysaccharides. Front Pharmacol. 2025.

[3] Martins AS, et al. Risks of Oral Anticoagulants: Interactions with Drugs and Herbal Medicines. Diseases. 2025.

Lemon Balm Extract (Melissa officinalis)

Lemon balm (Melissa officinalis L.) is a lemon-scented herb in the mint family (Lamiaceae) whose leaf has long been used in teas and is now commonly prepared as dried leaf, tinctures, and standardized extracts. Its phytochemical profile is often described by hydroxycinnamic acids (especially rosmarinic acid), flavonoids, and aromatic volatile constituents such as citral and citronellal, and many commercial extracts use rosmarinic acid as a standardization or quality marker.[1] Mechanistic research has explored how lemon balm may interact with pathways linked to relaxation and cognitive performance; one commonly discussed mechanism is inhibition of GABA transaminase (GABA-T) by rosmarinic acid, an enzyme involved in GABA breakdown, which provides a plausible biochemical rationale for why standardized lemon balm preparations are evaluated for perceived calm and sleep-quality outcomes.[1]

What it does in this formula

In Fmlave Menopause Support, lemon balm extract is included as a botanical component to support calm mood and sleep-quality habits as part of a consistent daily routine. It pairs naturally with magnesium citrate (often chosen for relaxation and healthy nerve-and-muscle function) and B vitamins (riboflavin and B6 as everyday metabolic cofactors), helping the formula feel steady and routine-friendly during the transition. Human clinical research has evaluated standardized lemon balm preparations for sleep and well-being quality measures, supporting its role as a gentle, everyday botanical in calm-focused blends.[2]

References

[1] Mathews IM, Eastwood J, Lamport DJ, et al. Clinical Efficacy and Tolerability of Lemon Balm (Melissa officinalis L.) in Psychological Well-Being: A Review. Nutrients. 2024.

[2] Di Pierro F, et al. Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study. Nutrients. 2024.

[3] Lobach AR, Schmidt F, Fedrizzi D, et al. Toxicological safety evaluation of an aqueous lemon balm (Melissa officinalis) extract. Food Chem Toxicol. 2024.

Chasteberry (Vitex agnus-castus) Fruit

Chasteberry, also called chaste tree berry, is the dried fruit of Vitex agnus-castus, a Mediterranean shrub traditionally used in women’s herbal preparations. The fruit contains several well-characterized compound families that show up repeatedly in quality discussions: iridoid glycosides (such as agnuside and aucubin), flavonoids (including apigenin and casticin), diterpenes, and aromatic essential-oil constituents.[2] Modern extracts are often discussed in the context of neuroendocrine signaling, especially dopaminergic activity; specific diterpene fractions from Vitex fruit extracts have been studied for interactions with dopamine D2 receptors, offering a plausible biochemical rationale for why the ingredient is commonly positioned around “cycle rhythm” and monthly comfort narratives in supplements.[1] As with many botanicals that interface with hormone-related signaling, responsible use language commonly emphasizes short-term tolerability and appropriate caution for people who are pregnant/nursing, using hormone-based medications, or managing hormone-sensitive conditions.[3]

What it does in this formula

In Fmlave Menopause Support, chasteberry fruit is included as part of the women’s botanical complex to support midlife comfort and a steadier day-to-day rhythm during the transition. It complements lemon balm’s calm-focused profile and magnesium’s role in relaxation and neuromuscular function, helping the formula feel like consistent, routine-friendly support. The intent is structure/function support—supporting overall well-being, mood steadiness, and temperature comfort as part of a daily wellness habit—without drug-like or symptom-specific positioning.

References

[1] Reinhardt JK, et al. Vitex agnus castus Extract Ze 440: Diterpene and Triterpene’s Interactions with Dopamine D2 Receptor. Planta Med. 2024.

[2] National Library of Medicine. Chasteberry. Drugs and Lactation Database (LactMed). 2024.

[3] National Center for Complementary and Integrative Health. Chasteberry: Usefulness and Safety. NCCIH. 2024.

Soy Bean Extract (Soy Isoflavones)

Soy bean extract in supplements commonly refers to a concentrated source of soy isoflavones—most notably genistein, daidzein, and glycitein—naturally occurring polyphenols found in Glycine max. Isoflavones are often described as “phytoestrogens” because their structure allows them to bind estrogen receptors, but they tend to behave more like selective estrogen receptor modulators (SERMs) than the body’s estrogen, with preferential binding to ERβ relative to ERα in many experimental contexts.[2] How a person responds to soy isoflavones can also vary because absorption and metabolism depend partly on gut microbiota (including whether someone is an “equol producer”), and because supplement products can differ in dose and isoflavone form (glycosides vs aglycones).[2] In controlled trials in postmenopausal women, meta-analytic evidence has found soy isoflavone supplementation did not produce significant changes in several clinical “estrogenicity” markers (such as endometrial thickness and estradiol) compared with non-isoflavone controls, supporting the idea that isoflavones are not equivalent to hormone therapy.[1]

What it does in this formula

In Fmlave Menopause Support, soy bean extract (soy isoflavones) is included as part of the women’s botanical complex to support everyday midlife comfort and overall well-being during the transition. It’s intended to work as a routine-friendly “steady base” alongside Vitamin D3, riboflavin, vitamin B6, and magnesium citrate—nutrients commonly used to support daily metabolic function, neuromuscular function, and bone-health habits—while keeping the product framed as structure/function support rather than drug-like relief. Because soy is a major food allergen and concentrated soy extracts can cause digestive upset in some people, it’s important to follow the labeled serving and avoid use if you have a soy allergy; if you are pregnant/nursing or using prescription medications, consult a healthcare professional before use.[3]

References

[1] Viscardi G, et al. Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Advances in Nutrition. 2025.

[2] Messina M, Barnes S, Setchell KDR. Perspective: Isoflavones—Intriguing Molecules but Much Remains to Be Learned about These Soybean Constituents. Advances in Nutrition. 2025.

[3] National Center for Complementary and Integrative Health. Soy: Usefulness and Safety. NCCIH. 2026.

Black Cohosh (Actaea racemosa) Root

Black cohosh is the root and rhizome of Actaea racemosa (syn. Cimicifuga racemosa), a North American botanical used in women’s herbal products. In supplements it is typically provided as a dried root/rhizome powder or as a hydroalcoholic extract, and quality discussions often focus on cycloartane-type triterpene glycosides (commonly tracked with markers such as actein/26-deoxyactein) as characteristic constituents used for identity and standardization approaches.[1] Mechanistic literature has explored several non-hormone pathways (including serotonergic and neurochemical signaling) as plausible rationales for why black cohosh is studied in midlife wellness contexts, although results can vary across extract types and study designs.[3] As with many botanicals, product integrity matters because misidentification or adulteration can affect consistency and tolerability.

What it does in this formula

In Fmlave Menopause Support, black cohosh root is included as part of the women’s botanical complex to support overall comfort and well-being during the transition, alongside foundational nutrients (Vitamin D3, riboflavin, vitamin B6, and magnesium citrate) that support bone, neuromuscular, and everyday metabolic function. This is positioned as routine-based structure/function support rather than drug-like relief. Safety note: rare cases of serious liver injury have been reported in people taking products labeled as black cohosh, and it is uncertain whether black cohosh was the cause in all cases; avoid use if you have liver disease, and stop use and consult a healthcare professional if signs of liver problems occur.[2]

References

[1] He K, et al. Direct analysis and identification of triterpene glycosides by LC/MS in black cohosh (Cimicifuga racemosa) and in several commercially available black cohosh products. Planta Med. 2000.

[2] National Center for Complementary and Integrative Health. Black Cohosh: Usefulness and Safety. NCCIH. 2024.

[3] National Cancer Institute. Black Cohosh (PDQ®)—Health Professional Version. NCI. 2024.