NATTOKINASE 18-IN-1 POTENT BLEND

What is this ingredient? Vitamin C, provided here as ascorbic acid, is an essential water‑soluble vitamin that humans must obtain from the diet. It functions as a key antioxidant and as a cofactor for several enzymes involved in collagen synthesis and catecholamine and carnitine production. In the vasculature, vitamin C scavenges reactive oxygen species and helps regenerate other antioxidants, contributing to protection of endothelial cells and lipoproteins from oxidative damage [0,2].

Clinical and meta‑analytic data indicate that vitamin C supplementation can improve endothelial function, particularly in individuals with existing cardiovascular risk such as atherosclerosis, diabetes, or heart failure [2,8]. Meta‑analysis of randomized trials has also shown that antioxidant vitamins, including vitamin C, have a small but significant beneficial effect on arterial stiffness, with more pronounced effects in people starting with lower plasma vitamin C levels [3]. These findings support vitamin C’s role as a vascular‑supportive micronutrient in at‑risk populations.

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND pairs vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, proteolytic enzymes, rutin, amla, CoQ10, and black pepper, clearly targeting circulatory health, fibrinolytic balance, and vascular integrity. Within this architecture, vitamin C is the foundational "endothelial and collagen" pillar. By supporting collagen cross‑linking, it contributes to the structural stability of blood vessel walls, while its antioxidant activity helps protect the endothelium from oxidative and inflammatory insults that can impair vasodilation [0,2,3].

Improved endothelial function with vitamin C supplementation has been documented in patients with cardiovascular risk factors and in some inflammatory conditions, aligning with the formula’s use of nattokinase, lumbrokinase, serrapeptase, and turmeric to support healthy circulation and vessel comfort [2,4,8]. In combination with bioflavonoids like rutin and amla and mitochondrial cofactors such as CoQ10, vitamin C helps create a redox environment that favors flexible, resilient vessels and complements the blend’s enzymatic support for healthy blood flow.

References

• [0] Vitamin C blocks vascular dysfunction and release of interleukin‑6 induced by endothelin‑1 in humans in vivo
• [2] Effect of vitamin C on endothelial function in health and disease: a systematic review and meta‑analysis of randomised controlled trials
• [3] Antioxidant vitamin supplementation reduces arterial stiffness in adults: a systematic review and meta‑analysis of randomized controlled trials

What is this ingredient? Vitamin B6, provided here as pyridoxine hydrochloride, is a water‑soluble vitamin that is converted in the body to pyridoxal‑5′‑phosphate (PLP), the active coenzyme form. PLP is required for more than 100 enzymatic reactions, especially in amino‑acid metabolism, neurotransmitter synthesis, and one‑carbon/transsulfuration pathways [4]. In homocysteine metabolism, PLP is a cofactor for cystathionine β‑synthase and related enzymes that convert homocysteine to cystathionine and cysteine, helping to keep homocysteine levels within a normal range [4,5].

Low vitamin B6 status has been associated with higher fasting homocysteine and an increased risk of venous and arterial thrombotic events in observational studies [0,5,7]. Although large outcome trials of B‑vitamin homocysteine‑lowering regimens have not demonstrated clear reductions in cardiovascular events overall, vitamin B6 remains important for maintaining normal amino‑acid handling and vascular biochemical balance [6,8].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, a botanical protease blend, rutin, amla, CoQ10, and black pepper, clearly targeting circulatory health, fibrinolytic balance, and vascular comfort. Within this architecture, vitamin B6 serves as a "homocysteine and amino‑acid" pillar. By supporting PLP‑dependent enzymes in the transsulfuration pathway, B6 helps prevent accumulation of homocysteine, a sulfur amino acid that is associated with endothelial dysfunction and pro‑thrombotic changes when elevated [4,5].

This biochemical support complements the more direct fibrinolytic actions of nattokinase and lumbrokinase, the antioxidant and anti‑inflammatory roles of vitamin C and turmeric, and the mitochondrial support of CoQ10. Together, they address both the mechanical side of circulation (enzyme blends affecting clot‑related proteins) and the metabolic milieu (B6, magnesium, and others shaping amino‑acid and vascular chemistry), aligning with the product’s goal of promoting smoother, more resilient blood flow and vessel health from multiple angles.

References

• [0] Homocysteine, vitamin B6 and the risk of recurrent venous thromboembolism
• [4] Vitamin B6 deficiency, genome instability and cancer
• [5] B vitamins and homocysteine in cardiovascular disease and aging
• [6] Homocysteine and vitamins in cardiovascular disease
• [8] Homocysteine‑lowering interventions for preventing cardiovascular events

What is this ingredient? Calcium, provided here as calcium carbonate, is an essential mineral best known for its role in building and maintaining bones and teeth. It also contributes to normal muscle contraction, nerve transmission, and blood clotting. In people with low dietary calcium, randomized trials show that calcium carbonate supplementation can improve bone mineral accretion and reduce age‑related bone loss, particularly in growing children and postmenopausal women [2,3,9].

Calcium carbonate is a dense, commonly used form that is absorbed best when taken with food. While some meta‑analyses have raised concerns about high‑dose calcium supplements and cardiovascular risk, more recent pooled analyses of randomized trials have not found significant increases in coronary heart disease, stroke, or all‑cause mortality with calcium (with or without vitamin D), though they emphasize tailoring supplemental doses to individual dietary intakes [1,5,8].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, a botanical protease blend, rutin, amla, CoQ10, and black pepper, clearly focusing on circulatory health, fibrinolytic balance, and vascular comfort. Within that architecture, calcium carbonate plays a more foundational "structural and ionic" role. Adequate calcium intake supports normal vascular smooth‑muscle contraction and neuromuscular function and helps maintain skeletal integrity while other ingredients focus more directly on blood flow and endothelial health.

In combination with magnesium, calcium helps stabilize excitability of muscles and nerves, which is relevant for vascular tone and cardiac rhythm. Ensuring baseline calcium sufficiency also allows vitamin C, B6, CoQ10, and the enzyme complexes to operate in a body that has its fundamental mineral needs met, reinforcing the product’s broader goal of supporting long‑term cardiovascular resilience without neglecting basic bone and muscle health [2,3,5,9].

References

• [1] Calcium Supplements and Risk of CVD: A Meta-Analysis of Randomized Trials
• [2] Double-blind, controlled calcium supplementation and bone mineral accretion in children accustomed to a low-calcium diet
• [3] Calcium supplementation increases stature and bone mineral mass of 16- to 18-year-old boys
• [5] The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials
• [9] Calcium supplementation and bone loss in middle-aged women

What is this ingredient? Magnesium, here as magnesium oxide, is an essential mineral involved in more than 300 enzyme‑catalyzed reactions. It supports ATP production, neuromuscular signaling, and regulation of vascular tone through its effects on smooth‑muscle relaxation and calcium handling. Many adults consume less than recommended amounts, and low magnesium status has been linked with higher blood pressure and other cardiometabolic issues.

Meta‑analyses of randomized, double‑blind, placebo‑controlled trials show that oral magnesium supplementation produces modest but statistically significant reductions in blood pressure. Typical elemental doses around 350–450 mg/day lower systolic pressure by roughly 2–4 mmHg and diastolic pressure by about 2 mmHg, with larger effects seen in people with hypertension, insulin resistance, or low baseline magnesium [0,3,5,6]. An umbrella meta‑analysis of randomized trials published up to 2024 likewise found small yet significant overall decreases in both systolic and diastolic blood pressure with magnesium supplements [6].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, botanical proteases, rutin, amla, CoQ10, and black pepper, clearly targeting circulatory health, fibrinolytic balance, and vascular comfort. Within that architecture, magnesium oxide serves as a core "electrolyte and vascular‑tone" pillar. By supporting smooth‑muscle relaxation and modestly lowering blood pressure in at‑risk groups, magnesium helps reduce mechanical stress on vessel walls and supports more comfortable blood‑flow dynamics [0,3,5,6].

Magnesium also partners with calcium in neuromuscular stability, and with vitamin B6 and CoQ10 in energy and metabolic pathways relevant to the heart and vasculature. While nattokinase, lumbrokinase, and serrapeptase focus on protein and fibrin turnover, magnesium addresses the pressure and tone side of the circulatory equation. Together, these actions align with the product’s goal of promoting smoother, more resilient circulation through complementary structural, enzymatic, and hemodynamic support.

References

• [0] Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials
• [3] The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials
• [5] The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
• [6] Impact of Magnesium Supplementation on Blood Pressure: An Umbrella Meta-Analysis of Randomized Controlled Trials

What is this ingredient? Nattokinase is a fibrinolytic enzyme originally isolated from natto, a traditional Japanese food made by fermenting soybeans with Bacillus subtilis. It is measured in fibrinolytic units (FU); a potency of 4,000 FU/g indicates strong activity for breaking down fibrin, a key structural protein in blood clots. In human studies, nattokinase supplementation has been shown to lower blood pressure in people with pre‑hypertension or stage 1 hypertension: an 8‑week randomized, double‑blind trial using 2,000 FU/capsule reported net reductions of about 5–6 mmHg in systolic and nearly 3 mmHg in diastolic blood pressure versus placebo [0].

Other clinical work has found that nattokinase can reduce circulating levels of clotting factors such as fibrinogen, factor VII, and factor VIII over two months of supplementation, consistent with a mild antithrombotic effect [5]. A 2024 meta‑analysis of randomized trials concluded that nattokinase significantly reduced systolic and diastolic blood pressure, though lipid‑lowering effects were inconsistent and dose‑dependent [1]. Long‑term atherosclerosis outcomes remain mixed, with one multi‑year low‑risk trial showing no effect on carotid intima‑media thickness [2], while a large open‑label study suggested benefit at higher doses [4].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, botanical proteases, rutin, amla, CoQ10, and black pepper, clearly targeting circulatory health, fibrinolytic balance, and vascular comfort. Within this architecture, nattokinase is the flagship "fibrin and blood‑flow" pillar. By enhancing fibrinolytic activity and modestly lowering blood pressure in clinical studies [0,1,5], it supports smoother flow and helps counter the buildup of pro‑coagulant proteins that can stiffen or narrow vessels.

Paired with lumbrokinase, serrapeptase, and a broader botanical protease blend, nattokinase anchors the enzymatic side of the formula, while vitamin C, rutin, and amla support vessel walls and CoQ10 and magnesium assist vascular tone and energy handling. In this way, nattokinase helps define the product’s core promise: not just general cardiovascular nutrition, but targeted support for healthy clot dynamics and comfortable, resilient circulation.

References

• [0] Effects of nattokinase on blood pressure: a randomized, controlled trial
• [1] Nattokinase supplementation and cardiovascular risk factors: a systematic review and meta-analysis of randomized controlled trials
• [2] Nattokinase atherothrombotic prevention study: a randomized controlled trial
• [4] Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: a clinical study with 1,062 participants
• [5] Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects

What is this ingredient? Turmeric (Curcuma longa) root extract is a concentrated source of curcuminoids, with curcumin as the best‑known component. Curcumin has been extensively studied for its antioxidant and inflammation‑modulating properties. In adults with chronic inflammatory and metabolic conditions, dose‑response meta‑analyses of randomized trials show that turmeric/curcumin supplementation significantly lowers inflammatory markers such as C‑reactive protein, TNF‑α, and IL‑6, while improving markers of oxidative status [3,9].

Curcumin has also been investigated for cardiovascular‑related endpoints. Randomized trials report improvements in endothelial function, measured by flow‑mediated dilation, after several weeks of curcumin supplementation in otherwise healthy adults, suggesting a beneficial effect on vessel reactivity [0,9]. In patients with type 2 diabetes and elevated atherogenic risk, curcumin-containing regimens have produced favorable changes in lipid fractions and arterial stiffness indices over months of use [4,10].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, botanical proteases, rutin, amla, CoQ10, black pepper, and turmeric, clearly targeting circulatory health, fibrinolytic balance, and vascular comfort. Within that architecture, turmeric extract is a core "inflammatory and vascular‑health" pillar. By lowering key inflammatory cytokines and improving oxidative balance [3,9], curcumin helps protect the endothelium and vessel wall from low‑grade inflammatory stress that can accompany modern lifestyles.

These anti‑inflammatory and antioxidant actions complement nattokinase and lumbrokinase, which focus on fibrin and clot‑related proteins, and CoQ10 and magnesium, which support mitochondrial and vascular smooth‑muscle function. Evidence that curcumin can enhance endothelial function and reduce arterial stiffness measures in cardiometabolic patients [0,4,9,10] fits well with the product’s aim of promoting smoother, more resilient circulation. In short, turmeric helps ensure that blood is not only flowing more freely through enzyme support, but also through vessels that are less inflamed and more responsive.

References

• [0] Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study
• [3] Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials
• [4] The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial
• [9] The effects of curcumin supplementation on biomarkers of inflammation, oxidative stress, and endothelial function: A meta-analysis of meta-analyses
• [10] The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial

What is this ingredient? The Botanical Protease Proprietary Blend combines two plant-derived proteolytic enzymes: bromelain from pineapple and papain from papaya. These enzymes help break down proteins into smaller peptides and amino acids. When taken orally, they act locally in the gut to assist protein digestion, and some evidence suggests that small amounts of protease activity or peptides may be absorbed and influence systemic protein turnover and inflammatory signaling, although this remains an active area of research.

Bromelain and papain have a long history of use in supporting comfort in tissues that are under mechanical or inflammatory stress. Their proteolytic activity allows them to interact with excess or damaged proteins in biological fluids in experimental models, which has led to their use in enzyme complexes aimed at modulating the balance between protein deposition and clearance.

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND pairs vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, rutin, amla, CoQ10, black pepper, and this Botanical Protease Blend to target circulatory health, fibrinolytic balance, and vascular comfort. Within that architecture, the bromelain–papain complex serves as an "adjunct proteolytic" pillar. While nattokinase and lumbrokinase are more specifically fibrinolytic, bromelain and papain broaden the enzymatic profile, contributing additional protease activity that can help manage the turnover of various proteins in the bloodstream and interstitial spaces.

By pairing botanical proteases with targeted fibrinolytic enzymes, antioxidant nutrients (vitamin C, turmeric, amla, rutin), and vascular cofactors such as magnesium and CoQ10, the formula approaches circulatory comfort from multiple angles: clot dynamics, inflammatory tone, oxidative balance, and vessel structure. The Botanical Protease Proprietary Blend helps knit these pieces together, supporting the overall goal of smoother, more comfortable circulation and tissue recovery in the context of everyday physical demands.

What is this ingredient? Japanese Pagoda Rutin is an extract from the flower buds of Sophora japonica, standardized for rutin, a flavonoid glycoside of quercetin. Rutin is widely recognized for its vascular-protective, antioxidant, and anti‑inflammatory properties. In endothelial cell and animal models, rutin helps preserve barrier integrity, reducing permeability, expression of adhesion molecules, and leukocyte migration in response to inflammatory stimuli such as lipopolysaccharide [10]. It also enhances endogenous antioxidant defenses and limits oxidative damage by modulating pathways like Nrf2 and reducing reactive oxygen species [1,8].

Recent mechanistic work shows that rutin can protect endothelial and cardiac tissues under oxidative or ischemic stress by dampening Nox4‑driven ROS production and inhibiting inflammatory signaling complexes such as the NLRP3 inflammasome and NF‑κB, thereby reducing cell injury and improving vascular relaxation [1,4,9,10]. Collectively, these actions position rutin as a targeted flavonoid for microvascular stability and cardioprotection.

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND includes vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, a botanical protease blend, amla, CoQ10, black pepper, and Japanese Pagoda Rutin, clearly focusing on circulatory health, fibrinolytic balance, and vascular comfort. Within this design, Japanese Pagoda Rutin is the key "capillary and endothelial barrier" pillar. While nattokinase and lumbrokinase act on fibrin and clot dynamics, rutin helps maintain tight endothelial junctions, reduces inflammatory adhesion molecules, and protects against oxidative stress–induced barrier disruption [1,4,8,10].

By stabilizing the inner lining of blood vessels and moderating ROS‑ and NF‑κB‑driven inflammatory responses, rutin complements vitamin C, turmeric, and amla on the antioxidant side, and CoQ10 and magnesium in supporting vascular function. This combination aims to ensure that blood flows not only more freely through enzyme support, but also through vessels whose walls are less leaky, less inflamed, and more resilient, aligning with the product’s goal of comprehensive, multi‑pathway circulatory support.

References

• [1] Rutin protects endothelial dysfunction by disturbing Nox4 and ROS-sensitive NLRP3 inflammasome
• [4] Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in human umbilical vein endothelial cells exposed to oxidative stress
• [8] The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds
• [10] Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo

What is this ingredient? Amla (Phyllanthus emblica), also known as Indian gooseberry, is a small, sour fruit traditionally used in Ayurvedic medicine. It is exceptionally rich in vitamin C and hydrolysable tannins (such as emblicanin A and B), which confer strong antioxidant properties [0,2,3]. Standardized amla extracts have been evaluated in multiple human trials for effects on cardiovascular risk factors, oxidative stress, and metabolic health. In adults with dyslipidemia or metabolic syndrome, 12 weeks of amla extract supplementation significantly lowered total cholesterol, LDL‑cholesterol, triglycerides, and high‑sensitivity C‑reactive protein, while improving HDL‑cholesterol and atherogenic indices compared with placebo [0,1,2,8,9].

Amla has also shown benefits for endothelial function and oxidative stress markers. In patients with metabolic syndrome or type 2 diabetes, standardized amla extract improved reactive hyperemia index (a measure of endothelial function) and increased antioxidant biomarkers such as nitric oxide and glutathione while reducing malondialdehyde and hs‑CRP [6,8]. In uremic patients, 4 months of amla supplementation reduced 8‑iso‑prostaglandin and increased total antioxidant status, indicating a systemic reduction in oxidative stress [3].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, botanical proteases, Japanese pagoda rutin, amla, CoQ10, and black pepper, clearly targeting circulatory health, fibrinolytic balance, and vascular comfort. Within that architecture, amla fruit extract is a key "polyphenol and antioxidant cardiometabolic" pillar. Its clinically demonstrated ability to improve endothelial function, lower atherogenic lipids, and reduce hs‑CRP and oxidative‑stress markers [1,2,3,6,8,9] directly supports healthier vessel walls and blood chemistry.

These actions complement nattokinase and lumbrokinase, which focus on fibrin and clot dynamics, and turmeric, rutin, vitamin C, and CoQ10, which support additional anti‑inflammatory and antioxidant pathways. By providing a concentrated, human‑studied botanical that addresses lipids, oxidative stress, and endothelial health at once, amla helps ensure the formula is not only working on the mechanical aspects of blood flow, but also on the underlying biochemical terrain that influences long‑term vascular resilience.

References

• [1] A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia
• [2] Evaluation of the effects of a standardized aqueous extract of Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress, systemic inflammation and lipid profile in subjects with metabolic syndrome: a randomised, double blind, placebo controlled clinical study
• [3] Supplementation of Emblica officinalis (Amla) extract reduces oxidative stress in uremic patients
• [6] Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study
• [8] Supplementation of a standardized extract from Phyllanthus emblica improves cardiovascular risk factors and platelet aggregation in overweight/class‑1 obese adults

What is this ingredient? Serrapeptase (also called serratiopeptidase) is a proteolytic enzyme originally isolated from the intestinal bacteria of the silkworm. Its activity is expressed in SPU (serrapeptase units), and 120,000 SPU denotes a highly potent preparation. As a protein‑digesting enzyme, serrapeptase can help break down certain non‑living protein substrates, including components of inflammatory exudates, mucus, and some extracellular protein accumulations, which is why it is often used in enzyme formulas aimed at tissue comfort and recovery.

In supplemental form, serrapeptase is typically enteric‑coated so it can pass through the stomach and act in the small intestine and beyond. While more large, high‑quality human trials are still needed, smaller clinical and traditional use data suggest serrapeptase can support normal inflammatory responses and help the body clear protein‑rich debris in areas under mechanical or inflammatory stress.

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, a botanical protease blend, Japanese pagoda rutin, amla, CoQ10, and black pepper, clearly targeting circulatory health, fibrinolytic balance, and vascular comfort. Within this architecture, serrapeptase is a key "tissue-protein and comfort" pillar, complementing nattokinase and lumbrokinase, which focus more directly on fibrin and clot‑related proteins.

By adding a broad‑acting protease with a history of use for swelling and congestion in soft tissues, the formula extends its support beyond the bloodstream to include perivascular and surrounding tissues. Paired with turmeric, rutin, amla, and vitamin C for antioxidant and inflammatory‑tone support, and with CoQ10 and magnesium for vascular energy and tone, serrapeptase helps create a more comprehensive enzyme matrix aimed at promoting smooth flow, easier tissue recovery, and overall circulatory comfort.

What is this ingredient? Coenzyme Q10 (CoQ10), provided here as ubiquinone, is a fat‑soluble, vitamin‑like compound found in virtually all cell membranes, with especially high concentrations in the mitochondria of heart and skeletal muscle. It plays a central role in the electron transport chain, shuttling electrons between complexes and enabling efficient ATP production. In its reduced form (ubiquinol), CoQ10 also functions as a lipid‑phase antioxidant, helping protect cell and lipoprotein membranes from oxidative damage [0,4].

Randomized controlled trials in people with ischemic heart disease and systolic heart failure show that CoQ10 supplementation can improve endothelial function, increase flow‑mediated dilation, and enhance markers of mitochondrial performance compared with placebo [1,4,8]. Larger outcome trials such as Q‑SYMBIO found that long‑term CoQ10 use in chronic heart failure reduced major adverse cardiovascular events and cardiovascular and all‑cause mortality versus placebo, while improving NYHA functional class over two years [5].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, turmeric, a botanical protease blend, Japanese pagoda rutin, amla, CoQ10, and black pepper to support circulatory health, fibrinolytic balance, and vascular comfort. Within this design, CoQ10 is the "mitochondrial energy and endothelial" pillar. By enhancing mitochondrial ATP production and improving endothelial function, CoQ10 supports the energetic demands of the heart and vascular smooth muscle, complementing the blend’s enzymatic actions on fibrin and protein deposits [1,4,5,8].

CoQ10’s antioxidant role also helps protect the endothelium and LDL particles from oxidative stress, working synergistically with vitamin C, rutin, turmeric, and amla. This is particularly relevant in a formula that promotes healthy clot dynamics: while nattokinase and lumbrokinase focus on blood rheology and fibrin turnover, CoQ10 helps ensure that the vessel wall and cardiac muscle remain energized and resilient, aligning with the product’s goal of smoother, more robust circulation over the long term.

References

• [0] Randomised double-blind, placebo-controlled trial of coenzyme Q10 therapy in class II and III systolic heart failure
• [1] Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
• [4] Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials
• [5] The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO, a randomized double-blind trial
• [8] Six-month supplementation with high-dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with MASLD: a randomized double-blind, placebo-controlled trial

What is this ingredient? Black Pepper (Piper nigrum) fruit extract standardized to 95% piperine is a highly concentrated form of the pungent alkaloid that gives black pepper its characteristic heat. Piperine is best known in nutrition science as a bioavailability enhancer: it can influence digestive enzymes, intestinal transporters, and first‑pass metabolism, which in turn can increase the absorption and systemic exposure of certain co‑administered nutrients and phytochemicals.

Human pharmacokinetic studies with various botanicals and nutrients have shown that piperine co‑administration can raise peak plasma concentrations and overall exposure of partner compounds, largely by slowing their metabolic breakdown and efflux from intestinal cells. This property makes piperine particularly useful in multi‑ingredient formulas, where each active is present in moderate amounts and efficient uptake is important.

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND brings together vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, a botanical protease blend, turmeric, Japanese pagoda rutin, amla, CoQ10, and black pepper to support circulatory health, fibrinolytic balance, and vascular comfort. Within this design, black pepper extract is the "absorption and synergy" pillar. Its piperine content is included to help enhance the bioavailability of several key fat‑soluble and polyphenolic ingredients—especially turmeric (curcumin), CoQ10, and amla/rutin flavonoids—as well as potentially supporting uptake of certain enzyme compounds.

By modestly improving how well these actives are absorbed and retained, standardized black pepper extract acts as a small but important catalyst. It does not drive circulation or fibrinolysis on its own, but it can help the broader blend deliver more of its enzyme, antioxidant, and vascular‑supporting components into the bloodstream, aligning with the product’s aim of comprehensive, multi‑pathway circulatory support.

What is this ingredient? Lumbrokinase is a group of fibrinolytic enzymes originally isolated from earthworms such as Lumbricus rubellus. Its potency is expressed in fibrinolytic units (FU); a strength of 10,000 FU/g indicates very high activity against fibrin, the main structural protein in blood clots. Lumbrokinase is considered highly fibrin‑specific, meaning it preferentially acts where fibrin is present rather than indiscriminately digesting circulating proteins, which may contribute to a lower hemorrhagic risk compared with non‑specific proteases [0,7].

Preclinical and emerging clinical research suggests that lumbrokinase has antithrombotic and tissue‑protective actions. It has been used in parts of Asia to help prevent secondary ischemic stroke and to support myocardial perfusion, and experimental models show benefits in ischemic stroke and myocardial ischemia–reperfusion injury through both fibrinolysis and attenuation of inflammatory signaling pathways such as TLR4 and NF‑κB [0,3,7]. A recent meta‑analysis of randomized controlled trials in acute ischemic stroke found that lumbrokinase, as an adjunct to standard care, improved functional scores with an acceptable safety profile, although more high‑quality trials are needed [2].

Why include it in this formula? The NATTOKINASE 18‑IN‑1 POTENT BLEND combines vitamin C, vitamin B6, calcium, magnesium, nattokinase, lumbrokinase, serrapeptase, botanical proteases, turmeric, Japanese pagoda rutin, amla, CoQ10, and black pepper to support circulatory health, fibrinolytic balance, and vascular comfort. Within this architecture, lumbrokinase is a flagship "earthworm‑derived fibrinolytic" pillar that complements nattokinase. Its potent, fibrin‑specific activity targets the protein meshwork involved in clot formation and post‑injury adhesions, adding another layer of support for healthy clot dynamics and microcirculation [0,2,5,7].

Because lumbrokinase also shows anti‑inflammatory and cardioprotective effects in ischemia models—reducing infarct size and modulating ER‑stress and inflammatory pathways—it fits well alongside turmeric, rutin, amla, vitamin C, and CoQ10, which protect vessel walls and mitochondria from oxidative and inflammatory stress [0,3,5,7]. Combined with magnesium and B6, which help shape vascular tone and amino‑acid metabolism, lumbrokinase helps the formula approach circulatory resilience from both a mechanical (fibrin/clot) and biochemical (inflammation/energy) perspective.

References

• [0] Mechanisms of lumbrokinase in protection of cerebral ischemia
• [2] Therapeutic Potential of Lumbrokinase in Acute Ischemic Stroke: A Meta-Analysis of Efficacy and Safety
• [3] Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling
• [5] Lumbrokinase, a Fibrinolytic Enzyme, Prevents Intra-Abdominal Adhesion by Inhibiting the Migrative and Adhesive Activities of Fibroblast
• [7] Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke