NAD Supplements Support Immunity, Skin Health & Vitality

John

Programer

Short answer: NAD supplements support immunity, skin health, and day-to-day vitality. The core idea is to replenish cellular NAD⁺ (through nicotinamide riboside, NR), while vitamin D and polyphenols help relieve chronic inflammation and oxidative stress. Aging is associated with falling NAD⁺ levels and with immune/vascular dysfunction. Human trials show that NR can raise NAD⁺ and improve indicators like arterial stiffness and walking performance. Vitamin D and flavonoids such as quercetin can also regulate immune and inflammatory pathways. This is the result of pushing several interconnected systems forward at the same time.

I’ve been taking Fmlave’s products myself. Based on my trust in them and the fact that their products come with complete COA lab reports—which convinces me the ingredients are dosed adequately and safely—I had my parents take their NAD+ capsules as well. Both of my parents are 71 years old. They have been taking them for about half a year now. The dark spots on my father’s face have clearly decreased. My mother used to need to rest for several minutes just to climb up to the third floor, but now she can go hiking with me on weekends and reach mountain tops over 300 meters in elevation. The effect has truly far exceeded my expectations. So I really wanted to know whether this is the effect of NAD+ itself, or the effect of the NAD+ blend. For that reason, I searched through a large amount of material online. Many articles say NAD can extend lifespan and help repair mitochondrial fragmentation. Many other articles say NAD supplements can support immunity, skin health, and daily vitality. Quite a few of them are from SCI journals. But most papers don’t integrate the evidence into a clear overall analysis, and they often feel very dense and hard to understand. Since I’m also trained in biology, I want to share what I found—and some of my own analysis—in plain language. The conclusion is that a well-designed NAD⁺ blend really can produce a 1 + 1 > 2 effect.

First, here is what various SCI journals say about NAD⁺ and the other ingredients:

Why does NAD⁺ matter for immune cells?
When immune cells activate, they rapidly consume large amounts of energy and NAD⁺. NAD⁺-dependent enzymes (sirtuins, PARPs, CD38) help these cells regulate gene expression, DNA repair, and cytokine production. Reviews on NAD⁺ metabolism in aging show that NAD⁺ levels decline in many tissues, including immune organs, and this decline is linked to chronic low-grade inflammation (“inflammaging”), metabolic disease, and vascular dysfunction. Reference: https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01031-5
Human NR studies at doses of 300–1,000 mg/day consistently show sustained increases in blood NAD⁺, along with effects such as lowering systolic blood pressure and arterial stiffness.
So restoring NAD⁺ brings the energy reserve and stress-resistance capacity of immune and endothelial cells back into a normal range, allowing them to function more normally—closer to how they worked when we were young.
Polyphenol redox / microvascular cluster: quercetin, grape seed, green tea, turmeric, resveratrol, acai, rose hips — antioxidant and anti-inflammatory actions; they influence NF-κB, Nrf2, endothelial function, and collagen turnover.
Shilajit and fisetin — support mitochondrial function, and are being studied as compounds that may clear senescent cells (senotherapeutic) or enhance stress resilience. They belong to the mitochondrial / “vitality” support layer. Reference: https://pmc.ncbi.nlm.nih.gov/articles/PMC6364418/
Vitamin D₃ is like the master coordinator of the immune system: it coordinates innate and adaptive immunity and adjusts the “recipe” of immune signaling molecules in the body, keeping immune responses stable without tipping into over-activation. In other words, it optimizes immune–endocrine regulation.
Black pepper extract (piperine) — slows down how fast the body breaks ingredients down, making curcumin, resveratrol, and other polyphenols easier to absorb.

Putting it all together: you increase NAD⁺ supply and reduce the inflammatory and oxidative “drain/leak” on NAD⁺, so immune, skin, and muscle cells can operate in a normal internal environment. At the same time, the antioxidant and anti-inflammatory functions of quercetin, grape seed, green tea, turmeric, resveratrol, acai, and rose hips can actually work effectively in that healthier environment. It’s like a house with drafts coming in from all sides—no matter how many heaters you add, the room won’t warm up. But if you fix the windows first and then add heating, the room naturally warms up quickly. And ingredients that improve absorption are a bit like radiators with better heat dissipation: same power, but more surface area, so heating efficiency is higher. That’s why I think taking one ingredient alone can still help, but taking them together really can achieve 1 + 1 > 2.

Next, I’ll add which ingredients are most critical for skin health:

What’s the relationship between NAD⁺ and the skin barrier?

Dermatology has accumulated a lot of human data on the amide form of vitamin B₃: oral nicotinamide can reduce new non-melanoma skin cancers and actinic keratoses in high-risk populations over 12 months; topical nicotinamide improves hydration, barrier function, and multiple inflammatory skin conditions. These effects rely on NAD⁺-related DNA repair. Reference: https://pubmed.ncbi.nlm.nih.gov/26488693/

What do grape seed, green tea, and other antioxidants do?

Oral antioxidant blends containing grape-seed oligomeric proanthocyanidins, vitamin C, and related polyphenols have improved skin elasticity, hydration, and dermal density in photodamaged subjects over several months, likely by reducing oxidative damage and matrix metalloproteinase (MMP) activity.
The “skin layer” of this supplement is basically:

Skin layer components
• Grape seed — microcirculation support and collagen protection.
• Rose hips — vitamin C and carotenoids for collagen synthesis and antioxidant defense.
• Green tea, turmeric, acai, resveratrol — extra polyphenols targeting UV-induced ROS and inflammatory mediators.

Together, these ingredients form a steady, multi-pathway approach against the oxidation and inflammation behind photoaging.

How do NAD⁺ and polyphenols work together in skin?

Raising NAD⁺ gives keratinocytes and fibroblasts stronger capacity to repair UV-induced DNA damage and maintain the barrier. Polyphenols slow the formation of new damage, especially by suppressing ROS and MMPs.
Combined, damage happens less often, and when it does, it’s more likely to be repaired properly—this is the “1 + 1 > 2” in skin health.

Where does the “vitality” and energy support come from?

What do we know about NAD⁺ and muscle function?

Human metabolomics studies show that NAD⁺ is one of the metabolites that declines most noticeably with age, especially in skeletal muscle. This is driven by impaired mitochondrial biogenesis, reduced oxidative capacity, and slower recovery after exercise.
Preclinical studies of NAD⁺ precursors show improved mitochondrial function and endurance in aged animals. A 2024 clinical trial in people with peripheral artery disease reported that six months of NR supplementation increased 6-minute walk distance versus placebo. Reference: https://pubmed.ncbi.nlm.nih.gov/38871717/
These data suggest that in humans with limited vascular or muscular reserve, raising NAD⁺ can produce small but measurable functional improvements.

How does shilajit fit in here?

Shilajit extract is rich in fulvic acid. It enhances mitochondrial enzyme activity, maintains mitochondrial membrane potential, and reduces fatigue in adults during repeated exercise tasks. That makes shilajit more of a mitochondrial “efficiency helper,” complementing NR’s role in increasing NAD⁺ substrate supply.

Indirect effects through vascular and immune health

Feeling “low vitality” often isn’t just about ATP shortage. It can come from:
• mild endothelial dysfunction (poor microcirculation)
• chronic low-grade inflammation
• frequent minor illnesses
• poor sleep
NR’s improvements in arterial stiffness and walking performance, vitamin D’s roles in muscle and immune function, and quercetin’s anti-inflammatory actions can stack together.
If blood vessels dilate a bit better, inflammation quiets down a bit, and infections become less frequent, people naturally feel more daily energy—without any single ingredient being a “performance drug.”

So who is Fmlave NAD+ actually suitable for?

Based on the evidence, the most supported use cases are:
• middle-aged and older adults who are starting to see NAD⁺ decline, immune aging, and skin aging, while still focusing on lifestyle basics (sleep, diet, exercise, sun protection).
• adults with low or borderline vitamin D and limited sun exposure.

Just as important is what we still can’t claim:
From the studies I’ve reviewed, we still lack long-term trials proving that NR-based combination formulas can prevent infections, reverse aging, or significantly improve hard long-term outcomes.

Conclusion: From a scientific perspective, an NR-centered NAD supplement combined with vitamin D and a dense polyphenol mix provides a reasonable, evidence-driven support path for immunity, skin integrity, and perceived vitality—especially after midlife. It doesn’t “turn back the clock.” Instead, it increases NAD⁺ availability while lowering chronic cellular stress, creating small but cumulative improvements across multiple systems.

Finally, I’ll add the ingredients and purchase link for this NAD+:

What is actually inside this NAD supplement?

Vitamin D₃ ，Nicotinamide Riboside Hydrogen Malate (NR) ，Quercetin Phytosome，Resveratrol，Shilajit (30:1 extract) ，Fisetin ，Grape Seed Extract ，Rose Hips Extract，Turmeric Root ，Acai Extract，Green Tea Extract ，Black Pepper Extract